Belinal®: A Natural Solution for Brain Health and Cognition
The brain is the most complex and vital organ in the human body. It controls our thoughts, emotions, memory, learning, and behavior.
Belinal® is a natural extract from the branches of silver fir trees, which has been scientifically proven to have multiple benefits for brain health and cognition. Belinal® works by:
- Relaxing the brain arteries: Belinal® enhances the production of prostacyclin and endothelium derived hyperpolarizing factor, which are natural substances that relax the smooth muscle cells of the brain arteries. This improves blood flow and oxygen delivery to the brain.
- Reducing inflammation: Belinal® inhibits the activation of inflammatory pathways and cytokines, which are involved in the development and progression of cerebrovascular diseases and cognitive impairment.
- Scavenging free radicals: Belinal® exhibits potent antioxidant activity, both in vivo and in vitro. Belinal® neutralizes the harmful effects of free radicals, which are unstable molecules that cause oxidative damage to the brain cells and tissues. Oxidative stress is a major contributor to aging and neurodegeneration.
Relaxation of brain arteries by 15%
A study on isolated human brain arteries showed that Belinal® achieved a remarkable 15.3% relaxation of the vascular rings. From the diagram above it is evident that compared to ginkgo extract EGb 761®, Belinal® significantly relaxes human brain arteries after acute cumulative addition.
Belinal® is a safe, effective, and natural solution for maintaining and enhancing brain health and cognition at any age. Belinal® can help prevent and treat cerebrovascular diseases, improve memory and focus. Belinal® is the ultimate choice for anyone who wants to keep healthy brain. As an effective relaxant of human brain arteries and inhibitor of inflammation, Belinal® could play an important role in the future treatment and prevention of cerebro-vascular diseases and cognitive functions.
Mechanisms of Action
Belinal® is renowned for its high concentration of polyphenols—including procyanidins, phenolic acids, and lignans—along with beneficial polysaccharides. These compounds act synergistically to support brain health through multiple mechanisms:
- Vasorelaxation of smooth muscle cells through prostacyclin release mechanisms (PGI2) and through endothelium derived hyperpolarizing factor (EDHF).
- Anti-inflammatory activity (inhibition of COX-2 activity, suppression of expression of proinflammatory cytokines: tumour necrosis factor α (TNF-α), interleukin IL-6, IL-1β, suppression of COX-1 activity, inhibition of histamine release.
- Antioxidant activity by scavenge free radicals and reduce oxidative damage to brain cells. Certain polyphenols, such as flavonoids, have been shown to inhibit MAO (Monoamine Oxidase ) activity, thereby prolonging dopamine availability in the brain.
Suggested Dose of Belinal® in Your Formula
80-120 mg Dose
References
- Kreft S., Štrukelj B. Vasodilatation of human brain arteries and anti-inflammatory activity of the silver fir branch exract. Study report to be published soon.
- Drevenšek G, Lunder M, Tavčar Benkovič E, Mikelj A, Štrukelj B, Kreft S. Silver fir (Abies alba) trunk extract protects Guinea pig arteries from impaired functional responses and morphology due to an atherogenic diet. 2015; 22(9).
- W Yang1, K Cui, X Li, J Zhao, Z Zeng, R Song, X Qi, W Xu. Effect of Polyphenols on Cognitive Function: Evidence from Population-Based Studies and Clinical Trials. The Journal of Nutritiom, Health & Aging 2021;25(10):1190-1204