Longevity & Healthy Aging

Belinal® a new approach to Healthy Ageing and Longevity

At the biological level, aging reflects the progressive accumulation of cellular damage over time, leading to a gradual decline in physiological function. While life expectancy continues to increase, many of these additional years are often spent in compromised health.

Healthy aging focuses on maintaining functional capacity, resilience, and quality of life throughout later stages of life.

Your tree of life for healthy ageing

Belinal® a unique botanical extract enables broad interaction with key mechanisms associated with longevity and age-related functional decline.

Belinal® has been investigated in a series of clinical studies and scientific research  addressing biological processes closely linked to aging, including oxidative stress, inflammation, metabolic regulation, brain health, gut health, vascular function, and tissue regeneration. These studies provide mechanistic insight into how silver fir branch polyphenols and polysaccharides interact with cellular and molecular pathways relevant to healthy aging.

Mechanisms of Action

• Antioxidant activity inside cells: Belinal® protects cellular structures from oxidative stress, including telomeric DNA, and supports longevity-related signaling pathways such as SIRT6 activation.
• Anti-inflammatory modulation: Belinal® inhibits COX-2 and suppresses pro-inflammatory mediators including TNF-α, IL-6, and IL-1β, while also limiting histamine release.
• Metabolic health support: Belinal® acts as a carbohydrate blocker by inhibiting alpha-amylase and alpha-glucosidase, supporting glycemic control and metabolic balance.
• Cardiovascular and brain health: Belinal® supports vascular relaxation through prostacyclin and endothelium-derived mechanisms, contributing to healthy circulation and cognitive function.
• Joint and connective tissue health: Belinal® enhances the chondrogenic potential of mesenchymal stem cells and supports joint tissue regeneration.
• Skin structure and regeneration: Belinal® stimulates collagen and elastin synthesis, supporting dermal regeneration and skin quality.
• Gut microbiota interaction: Non-starch polysaccharides in Belinal® support beneficial gut bacteria, contributing to microbiota balance as a foundational aspect of healthy aging.[3.1][4.1]

Suggested Dose of Belinal® in Your Formula

100–140 mg

Directions:

1 dosage daily, preferably with a meal. Suitable for continuous use.

References:

1. Debeljak J, Ferk P, Čokolič M, Zavratnik A, Tavčar Benković E, Kreft S, Strukelj B. Randomised, double blind, cross-over, placebo and active controlled human pharmacodynamic study on the influence of silver fir wood extract (Belinal) on post-prandial glycemic response. Pharmazie. 2016; 71(10).
2. Drevenšek G, Lunder M, Tavčar Benkovič E, Mikelj A, Štrukelj B, Kreft S. Silver fir (Abies alba) trunk extract protects Guinea pig arteries from impaired functional responses and morphology due to an atherogenic diet. Phytomedicine. 2015; 22(9).
3. Drevenšek G, Lunder M, Tavčar Benković E, Štrukelj B, Kreft S. Cardioprotective effects of silver fir (Abies alba) extract in ischemic-reperfused isolated rat hearts. Food Nutr Res. 2016; 60(1).
4. Tavčar Benković E, Žigon D, Mihailović V, Petelinc T, Jamnik P, Kreft S. Identification, in vitro and in vivo Antioxidant Activity, and Gastrointestinal Stability of Lignans from Silver Fir (Abies alba) Wood Extract Belinal. J Wood Chem Technol [Internet]. 2017 Nov 2;37(6):467–77.
5. Lunder M, Roškar I, Hošek J, Štrukelj B. Silver Fir (Abies alba) Extracts Inhibit Enzymes Involved in Blood Glucose Management and Protect against Oxidative Stress in High Glucose Environment. Plant Foods for Human Nutrition. 2019 Mar; 74(1): 47–53.
6. Sirse M, Fokter K S, Strukelj B, Zupan J. Silver Fir (Abies alba) Polyphenolic Extract ( Belinal) Shows Beneficial Influence on Chondrogenesis In Vitro under Normal and Inflammatory Conditions.
7. Molecules 2020, 25, 4616
8. Kreft S. Phytochemical, pharmacological and clinical studies of an extract prepared from silver fir branches Belinal® (Abies alba). Biologia Serbica, 2021, 43(1): 57-62.
9. Stojanov S, Ravnikar M, Berlec A, Kreft S. Interaction between silver fir (Abies alba) wood water extract Belinal® and lactobacilli. Pharmazie 76 (2021)
10. Schoss K. , Benedetic R. and Kreft S. The Phenolic Content, Antioxidative Properties and extractable Substances in Silver Fir Branch (Abies alba Mill.) Branches Decrease with Distance from the Trunk. Plants 2022, 11, 333